This receptor is located in the membrane of the nerve cell and its hyperactivity causes cells to be less active, thereby delaying information rather than transmitting it. In addition, elevated expression of the protein synapsin2b was also found. Adding, "This area - the Dentate Gyrus in the hippocampus - as well as the molecules whose expression changed, are associated with epilepsy.When epilepsy model mice breed, the offspring is always born with epilepsy.In the present study, the researchers examined what happens to a mouse, which has undergone genetic modification causing total no expression of the protein eEF2K. In the first test, the researchers took a male mouse with no expression of eEF2K and a female epilepsy model mouse and bred them. (Representational Image) Washington D.
They found that the hippocampus shows increased expression of a sub-unit of a receptor called GABAAR. We were surprised to find that the molecular change we created led to a minor change in this relationship in the hippocampus, but also created resistance to epileptic seizures. This protein is key modulator of neurotransmitter release in neurons.""The aim of our study was to isolate molecular components that serve the creation of long-term memories. In this case, the offspring was born without epileptic seizures as shown by EEG tests.Taha&pump motor39;s work focuses on the study of the underlying processes behind the creation and preservation of memories. For example, mutation in synapsin2b in humans or a decline in its expression may lead to epilepsy.None of the tests identified damage to the consolidation of memory with the exception of one specific type of memory: context memory - the memory created relating to the context (usually the spatial context) of learning. Thus the finding creates new possibilities for developing drugs for the treatment of epilepsy," he said. The relationship between the activities of the nerve cells that cause the transfer of information and activities delaying the transmission of information is extremely important. In the second test, a substance inhibiting the expression of eEFK2 was injected into mice with epilepsy.C.
